MBOAT4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MBOAT4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MBOAT4 at tissue level.

III. Associated gene sets

GO_0016486Biological processpeptide hormone processing
GO_0018191Biological processpeptidyl-serine octanoylation
GO_0030258Biological processlipid modification
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016747Molecular functionacyltransferase activity, transferring groups other than amino-acyl groups
GO_0008374Molecular functionO-acyltransferase activity
GO_0016412Molecular functionserine O-acyltransferase activity

IV. Literature review

[source]
Gene nameMBOAT4
Protein nameGhrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4)
Membrane bound O-acyltransferase domain containing 4
SynonymsGOAT
FKSG89
OACT4
DescriptionFUNCTION: Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity . In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient . .

AccessionsQ96T53
E7DVW7
ENST00000320542.4 [Q96T53-1]