MBLAC2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MBLAC2 at tissue level.

III. Associated gene sets

GO_0006631Biological processfatty acid metabolic process
GO_0008150Biological processbiological_process
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0052816Molecular functionlong-chain fatty acyl-CoA hydrolase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0008800Molecular functionbeta-lactamase activity

IV. Literature review

[source]
Gene nameMBLAC2
Protein nameAcyl-coenzyme A thioesterase MBLAC2 (Acyl-CoA thioesterase MBLAC2) (EC 3.1.2.2) (Beta-lactamase MBLAC2) (EC 3.5.2.6) (Metallo-beta-lactamase domain-containing protein 2) (Palmitoyl-coenzyme A thioesterase MBLAC2)
Synonyms
DescriptionFUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH . Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) . Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18 . Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin . Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) . .

AccessionsENST00000316610.7 [Q68D91-1]
Q68D91
ENST00000514906.1 [Q68D91-2]