I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 6 studies | 79% ± 27% | |
| endothelial cell | 3 studies | 31% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 6 studies | 79% ± 27% | |
| endothelial cell | 3 studies | 31% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 3 studies | 49% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 98784.41 | 226 / 226 | 97% | 553.19 | 394 / 406 |
| ovary | 88% | 504.23 | 159 / 180 | 64% | 4.82 | 274 / 430 |
| pancreas | 100% | 2932.67 | 328 / 328 | 35% | 1.72 | 62 / 178 |
| skin | 71% | 612.05 | 1277 / 1809 | 46% | 12.52 | 218 / 472 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.34 | 1 / 1 |
| kidney | 53% | 82.49 | 47 / 89 | 19% | 2.73 | 171 / 901 |
| adrenal gland | 49% | 85.57 | 126 / 258 | 21% | 3.51 | 49 / 230 |
| lung | 34% | 89.68 | 198 / 578 | 33% | 2.62 | 377 / 1155 |
| eye | 0% | 0 | 0 / 0 | 43% | 2.60 | 34 / 80 |
| uterus | 11% | 22.65 | 18 / 170 | 30% | 3.27 | 138 / 459 |
| intestine | 3% | 3.62 | 27 / 966 | 35% | 4.19 | 186 / 527 |
| breast | 7% | 11.97 | 32 / 459 | 27% | 2.74 | 299 / 1118 |
| stomach | 1% | 0.98 | 4 / 359 | 29% | 2.04 | 84 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 27% | 1.56 | 12 / 45 |
| bladder | 0% | 0 | 0 / 21 | 24% | 1.77 | 120 / 504 |
| thymus | 13% | 15.01 | 83 / 653 | 10% | 0.47 | 59 / 605 |
| esophagus | 3% | 4.94 | 49 / 1445 | 19% | 1.75 | 34 / 183 |
| brain | 12% | 22.05 | 316 / 2642 | 1% | 0.03 | 5 / 705 |
| peripheral blood | 12% | 55.67 | 109 / 929 | 0% | 0 | 0 / 0 |
| adipose | 4% | 16.96 | 43 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.10 | 1 / 29 |
| prostate | 2% | 2.37 | 6 / 245 | 1% | 0.03 | 3 / 502 |
| spleen | 2% | 139.86 | 6 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 3.22 | 17 / 1335 | 0% | 0 | 0 / 0 |
| heart | 1% | 3.35 | 7 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.45 | 4 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006730 | Biological process | one-carbon metabolic process |
| GO_0006556 | Biological process | S-adenosylmethionine biosynthetic process |
| GO_0009087 | Biological process | methionine catabolic process |
| GO_0051289 | Biological process | protein homotetramerization |
| GO_0048269 | Cellular component | methionine adenosyltransferase complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004478 | Molecular function | methionine adenosyltransferase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | MAT1A |
| Protein name | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) Methionine adenosyltransferase 1A |
| Synonyms | MATA1 AMS1 |
| Description | FUNCTION: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. . |
| Accessions | Q00266 B1ANE6 ENST00000372213.8 ENST00000455001.1 |
