MASTL | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of MASTL at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	558.73	1445 / 1445	100%	17.29	183 / 183
breast	100%	716.72	459 / 459	100%	14.81	1115 / 1118
lung	100%	627.04	577 / 578	100%	13.37	1150 / 1155
ovary	100%	506.74	180 / 180	99%	12.79	426 / 430
bladder	100%	530.19	21 / 21	99%	14.17	499 / 504
uterus	100%	505.34	170 / 170	99%	17.80	454 / 459
intestine	100%	486.25	966 / 966	98%	11.27	517 / 527
stomach	100%	399.15	359 / 359	98%	11.63	280 / 286
thymus	100%	560.86	652 / 653	95%	6.88	574 / 605
prostate	100%	455.00	245 / 245	95%	5.57	475 / 502
pancreas	97%	249.70	318 / 328	96%	8.14	171 / 178
adrenal gland	100%	530.39	258 / 258	92%	8.09	212 / 230
skin	100%	1067.95	1809 / 1809	90%	10.57	427 / 472
kidney	100%	410.28	89 / 89	89%	6.29	799 / 901
brain	92%	259.49	2436 / 2642	90%	5.91	637 / 705
liver	100%	290.65	226 / 226	76%	5.30	309 / 406
adipose	100%	730.32	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	13.31	29 / 29
spleen	100%	614.56	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	18.57	45 / 45
ureter	0%	0	0 / 0	100%	9.68	1 / 1
blood vessel	100%	591.48	1334 / 1335	0%	0	0 / 0
heart	91%	227.47	782 / 861	0%	0	0 / 0
muscle	88%	192.02	710 / 803	0%	0	0 / 0
peripheral blood	88%	887.43	813 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	50%	2.73	40 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0000278	Biological process	mitotic cell cycle
GO_0032515	Biological process	negative regulation of phosphoprotein phosphatase activity
GO_0006974	Biological process	DNA damage response
GO_0051301	Biological process	cell division
GO_0035556	Biological process	intracellular signal transduction
GO_0007346	Biological process	regulation of mitotic cell cycle
GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_0007147	Biological process	female meiosis II
GO_0051726	Biological process	regulation of cell cycle
GO_0005813	Cellular component	centrosome
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0032154	Cellular component	cleavage furrow
GO_0005634	Cellular component	nucleus
GO_0051721	Molecular function	protein phosphatase 2A binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005524	Molecular function	ATP binding
GO_0016301	Molecular function	kinase activity

Gene name	MASTL
Protein name	Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) non-specific serine/threonine protein kinase (EC 2.7.11.1)
Synonyms	GW THC2 GWL
Description	FUNCTION: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. .
Accessions	ENST00000375946.8 [Q96GX5-3] ENST00000342386.10 [Q96GX5-2] A0A087WUU7 Q96GX5 ENST00000477034.2 ENST00000375940.9 [Q96GX5-1]

MASTL report