MASP1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MASP1 at tissue level.

III. Associated gene sets

GO_0001867Biological processcomplement activation, lectin pathway
GO_0031638Biological processzymogen activation
GO_0005615Cellular componentextracellular space
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0042803Molecular functionprotein homodimerization activity
GO_0008233Molecular functionpeptidase activity
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameMASP1
Protein nameMBL associated serine protease 1
Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
SynonymsPRSS5
CRARF1
CRARF
DescriptionFUNCTION: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development . .

AccessionsENST00000169293.10 [P48740-3]
F8W876
C9JLU5
ENST00000439271.1
ENST00000707993.1 [P48740-2]
ENST00000707990.1 [P48740-1]
P48740
ENST00000296280.11 [P48740-2]
ENST00000392472.6 [P48740-4]
ENST00000425937.1
C9J1C7
ENST00000392470.6
C9JMA2
ENST00000392475.2
ENST00000707996.1 [P48740-3]
ENST00000707994.1 [P48740-4]
ENST00000337774.10 [P48740-1]