MARCHF9 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MARCHF9 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0005802Cellular componenttrans-Golgi network
GO_0005795Cellular componentGolgi stack
GO_0000139Cellular componentGolgi membrane
GO_0005765Cellular componentlysosomal membrane
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMARCHF9
Protein nameE3 ubiquitin-protein ligase MARCHF9 (EC 2.3.2.27) (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX) (RING finger protein 179) (RING-type E3 ubiquitin transferase MARCHF9)
SynonymsMARCH9
RNF179
DescriptionFUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. .

AccessionsENST00000266643.6 [Q86YJ5-1]
Q86YJ5
ENST00000548358.1 [Q86YJ5-2]