MARCHF6-DT report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MARCHF6-DT at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MARCHF6-DT at tissue level.

III. Associated gene sets

GO_0010835Biological processregulation of protein ADP-ribosylation
GO_0045739Biological processpositive regulation of DNA repair
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0005730Cellular componentnucleolus
GO_0090734Cellular componentsite of DNA damage
GO_0005515Molecular functionprotein binding
GO_0072572Molecular functionpoly-ADP-D-ribose binding

IV. Literature review

[source]
Gene nameMARCHF6-DT
Protein namePoly-ADP-ribosylation-amplifying and CtIP-maintaining micropeptide (PAR-amplifying and CtIP-maintaining micropeptide)
SynonymsPACMP
DescriptionFUNCTION: Micropeptide that acts as a regulator of DNA repair both by preventing KLHL15-mediated ubiquitination and degradation of RBBP8/CtIP, and by promoting the poly-ADP-ribosyltransferase activity of PARP1 . Prevents KLHL15-mediated ubiquitination of RBBP8/CtIP by competitively blocking the association between KLHL15 and RBBP8/CtIP . Recruited to DNA damage sites via association with poly-ADP-ribose chains, and enhances the poly-ADP-ribosyltransferase activity of PARP1 . .

AccessionsP0DW81