MAG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098742Biological processcell-cell adhesion via plasma-membrane adhesion molecules
GO_0031103Biological processaxon regeneration
GO_0071260Biological processcellular response to mechanical stimulus
GO_0048711Biological processpositive regulation of astrocyte differentiation
GO_0032289Biological processcentral nervous system myelin formation
GO_0007155Biological processcell adhesion
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0010977Biological processnegative regulation of neuron projection development
GO_0030517Biological processnegative regulation of axon extension
GO_0019226Biological processtransmission of nerve impulse
GO_0031643Biological processpositive regulation of myelination
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0043209Cellular componentmyelin sheath
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0043220Cellular componentSchmidt-Lanterman incisure
GO_0033270Cellular componentparanode region of axon
GO_0097453Cellular componentmesaxon
GO_0043218Cellular componentcompact myelin
GO_0035749Cellular componentmyelin sheath adaxonal region
GO_0042803Molecular functionprotein homodimerization activity
GO_0033691Molecular functionsialic acid binding
GO_1905576Molecular functionganglioside GT1b binding
GO_0019901Molecular functionprotein kinase binding
GO_0030246Molecular functioncarbohydrate binding
GO_0005102Molecular functionsignaling receptor binding

IV. Literature review

[source]
Gene nameMAG
Protein nameMyelin-associated glycoprotein (Siglec-4a)
Myelin associated glycoprotein
SynonymsGMA
DescriptionFUNCTION: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity). .

AccessionsENST00000392213.8 [P20916-1]
ENST00000597035.5
ENST00000600291.5
ENST00000537831.2 [P20916-3]
ENST00000595791.5
M0R3I4
M0R3B9
P20916
M0QZU4
ENST00000361922.8 [P20916-2]