MAEA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043249Biological processerythrocyte maturation
GO_0051301Biological processcell division
GO_0007155Biological processcell adhesion
GO_0007010Biological processcytoskeleton organization
GO_0033033Biological processnegative regulation of myeloid cell apoptotic process
GO_0007346Biological processregulation of mitotic cell cycle
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0048822Biological processenucleate erythrocyte development
GO_0000151Cellular componentubiquitin ligase complex
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0005826Cellular componentactomyosin contractile ring
GO_0034657Cellular componentGID complex
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0005737Cellular componentcytoplasm
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameMAEA
Protein nameMacrophage erythroblast attacher, E3 ubiquitin ligase
E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Macrophage erythroblast attacher)
E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP)
E3 ubiquitin-protein transferase MAEA (Macrophage erythroblast attacher)
Macrophage erythroblast attacher, isoform CRA_c (cDNA FLJ34632 fis, clone KIDNE2015660, highly similar to Homo sapiens macrophage erythroblast attacher (MAEA), transcript variant 2, mRNA)
SynonymsPIG5
hCG_1646851
EMP
HLC10
DescriptionFUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex . MAEA is required for normal cell proliferation . The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 . Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis . Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable). .

AccessionsD6R8Z3
ENST00000512842.5
E7ESC7
ENST00000510794.5
D6RIB6
ENST00000513301.5
ENST00000514708.5
ENST00000509254.5
ENST00000503653.5
ENST00000505839.1
ENST00000505177.6
ENST00000502558.5
D6RE80
B4DQT1
B4DVN3
D6RDW4
D6REW7
Q7L5Y9
ENST00000303400.9 [Q7L5Y9-1]
B3KRN7
D6RID6
ENST00000264750.10 [Q7L5Y9-3]
ENST00000509531.5
D6RA86
ENST00000512308.5