I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 3 studies | 18% ± 1% | |
| glutamatergic neuron | 3 studies | 29% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 3 studies | 18% ± 1% | |
| glutamatergic neuron | 3 studies | 29% ± 10% |
Insufficient scRNA-seq data for expression of LZTR1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 100% | 4416.10 | 1809 / 1809 | 100% | 9.99 | 471 / 472 |
| uterus | 100% | 7517.73 | 170 / 170 | 100% | 7.84 | 458 / 459 |
| prostate | 100% | 6490.04 | 245 / 245 | 100% | 7.60 | 500 / 502 |
| adrenal gland | 100% | 5254.09 | 258 / 258 | 100% | 6.81 | 229 / 230 |
| brain | 99% | 4180.56 | 2626 / 2642 | 100% | 8.65 | 704 / 705 |
| bladder | 100% | 6134.48 | 21 / 21 | 99% | 8.69 | 500 / 504 |
| thymus | 100% | 6828.90 | 653 / 653 | 99% | 6.17 | 597 / 605 |
| pancreas | 100% | 2690.22 | 327 / 328 | 99% | 7.33 | 176 / 178 |
| esophagus | 100% | 5761.22 | 1445 / 1445 | 98% | 5.11 | 180 / 183 |
| liver | 100% | 2821.09 | 226 / 226 | 98% | 6.04 | 399 / 406 |
| breast | 100% | 6101.47 | 459 / 459 | 97% | 6.14 | 1089 / 1118 |
| kidney | 100% | 5727.16 | 89 / 89 | 97% | 7.07 | 875 / 901 |
| lung | 100% | 5625.04 | 578 / 578 | 96% | 6.04 | 1113 / 1155 |
| intestine | 100% | 6159.49 | 966 / 966 | 96% | 4.92 | 506 / 527 |
| stomach | 100% | 3952.11 | 359 / 359 | 93% | 4.39 | 266 / 286 |
| ovary | 100% | 6498.01 | 180 / 180 | 80% | 3.02 | 344 / 430 |
| adipose | 100% | 6075.82 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 6.96 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 7.45 | 29 / 29 |
| spleen | 100% | 6989.16 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.30 | 1 / 1 |
| blood vessel | 100% | 5628.36 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 3141.75 | 855 / 861 | 0% | 0 | 0 / 0 |
| muscle | 99% | 2580.43 | 795 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 4.84 | 43 / 45 |
| peripheral blood | 92% | 2321.92 | 851 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0046580 | Biological process | negative regulation of Ras protein signal transduction |
| GO_0055038 | Cellular component | recycling endosome membrane |
| GO_0031463 | Cellular component | Cul3-RING ubiquitin ligase complex |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0012505 | Cellular component | endomembrane system |
| GO_0005515 | Molecular function | protein binding |
| GO_0031267 | Molecular function | small GTPase binding |
| Gene name | LZTR1 |
| Protein name | Leucine zipper like transcription regulator 1 Leucine-zipper-like transcriptional regulator 1 (LZTR-1) |
| Synonyms | TCFL2 |
| Description | FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) . Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes . . |
| Accessions | A0A2R8Y656 ENST00000415354.6 ENST00000452988.5 ENST00000644435.1 ENST00000443265.5 ENST00000700578.1 H7BZQ9 ENST00000642151.1 ENST00000414985.5 A0A2R8Y7K3 A0A2R8Y4K9 ENST00000497716.5 F8WEQ8 A0A8V8TQF0 H7C305 Q8N653 ENST00000439171.5 H7C0X1 ENST00000415817.2 A0A2R8YCD2 F8WB67 ENST00000646124.2 ENST00000645935.1 F8WCB6 |
