LYSET report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LYSET at tissue level.

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0060627Biological processregulation of vesicle-mediated transport
GO_0007041Biological processlysosomal transport
GO_0000139Cellular componentGolgi membrane
GO_0005794Cellular componentGolgi apparatus
GO_0031985Cellular componentGolgi cisterna
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLYSET
Protein nameLysosomal enzyme trafficking factor (GNPTAB cleavage and activity factor) (GCAF) (Transmembrane protein 251)
SynonymsTMEM251
C14orf109
DescriptionFUNCTION: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes . LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes . LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases . .; FUNCTION: (Microbial infection) Essential for infection by muliple viruses, including SARS-CoV-2, that utilize activated cathepsins for entry after M6P-dependent lysosomal transport. .

AccessionsENST00000283534.4 [Q8N6I4-2]
Q8N6I4
ENST00000415050.3 [Q8N6I4-1]
ENST00000626767.1 [Q8N6I4-2]
ENST00000622205.2 [Q8N6I4-3]