LTB4R2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LTB4R2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LTB4R2 at tissue level.

III. Associated gene sets

GO_0007194Biological processnegative regulation of adenylate cyclase activity
GO_0061737Biological processleukotriene signaling pathway
GO_0007218Biological processneuropeptide signaling pathway
GO_0051546Biological processkeratinocyte migration
GO_0006935Biological processchemotaxis
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0004974Molecular functionleukotriene receptor activity
GO_0008528Molecular functionG protein-coupled peptide receptor activity
GO_0001632Molecular functionleukotriene B4 receptor activity

IV. Literature review

[source]
Gene nameLTB4R2
Protein nameLeukotriene B4 receptor 2
LTB4R2 protein
Leukotriene B4 receptor 2 (LTB4-R 2) (LTB4-R2) (LTB4 receptor JULF2) (Leukotriene B4 receptor BLT2) (Seven transmembrane receptor BLTR2)
SynonymsBLTR2
BLT2R
DescriptionFUNCTION: Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

AccessionsA1L156
E9PIC1
ENST00000643080.1
ENST00000533293.2
ENST00000527924.6
A0A3Q5ACI7
ENST00000528054.1
ENST00000543919.1
ENST00000530080.1
Q9NPC1
ENST00000644309.2
E9PNJ6