Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 5 studies | 27% ± 9% | |
| glutamatergic neuron | 5 studies | 40% ± 23% | |
| astrocyte | 5 studies | 26% ± 8% | |
| cardiac muscle cell | 4 studies | 21% ± 3% | |
| GABAergic neuron | 4 studies | 38% ± 19% | |
| microglial cell | 3 studies | 24% ± 2% | |
| oligodendrocyte precursor cell | 3 studies | 24% ± 5% | |
| macrophage | 3 studies | 23% ± 4% | |
| neuron | 3 studies | 23% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 33% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2002.99 | 1445 / 1445 | 100% | 10.65 | 183 / 183 |
| prostate | 100% | 2557.56 | 245 / 245 | 100% | 15.69 | 502 / 502 |
| intestine | 100% | 2748.43 | 966 / 966 | 100% | 10.75 | 526 / 527 |
| uterus | 100% | 2249.35 | 170 / 170 | 100% | 9.46 | 458 / 459 |
| ovary | 100% | 2260.32 | 180 / 180 | 100% | 8.43 | 429 / 430 |
| stomach | 100% | 1771.12 | 358 / 359 | 100% | 9.64 | 286 / 286 |
| thymus | 100% | 2177.93 | 653 / 653 | 100% | 10.12 | 603 / 605 |
| brain | 100% | 2359.00 | 2633 / 2642 | 100% | 16.42 | 705 / 705 |
| breast | 100% | 1687.83 | 459 / 459 | 100% | 12.69 | 1114 / 1118 |
| bladder | 100% | 2663.19 | 21 / 21 | 100% | 9.65 | 502 / 504 |
| adrenal gland | 100% | 2229.74 | 258 / 258 | 100% | 11.27 | 229 / 230 |
| kidney | 100% | 1944.65 | 89 / 89 | 100% | 9.82 | 897 / 901 |
| lung | 100% | 1802.91 | 576 / 578 | 99% | 8.46 | 1149 / 1155 |
| skin | 100% | 3376.34 | 1806 / 1809 | 99% | 9.40 | 468 / 472 |
| liver | 100% | 1341.98 | 226 / 226 | 98% | 7.27 | 399 / 406 |
| pancreas | 95% | 778.78 | 313 / 328 | 99% | 9.03 | 176 / 178 |
| eye | 0% | 0 | 0 / 0 | 100% | 13.29 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 10.89 | 29 / 29 |
| spleen | 100% | 2473.12 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 8.83 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.11 | 1 / 1 |
| blood vessel | 100% | 1826.75 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 1514.01 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1398.38 | 799 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 2102.11 | 845 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 1715.74 | 906 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045806 | Biological process | negative regulation of endocytosis |
| GO_0051865 | Biological process | protein autoubiquitination |
| GO_0006914 | Biological process | autophagy |
| GO_2000786 | Biological process | positive regulation of autophagosome assembly |
| GO_1904417 | Biological process | positive regulation of xenophagy |
| GO_0046755 | Biological process | viral budding |
| GO_0000209 | Biological process | protein polyubiquitination |
| GO_0070086 | Biological process | ubiquitin-dependent endocytosis |
| GO_0030163 | Biological process | protein catabolic process |
| GO_0005829 | Cellular component | cytosol |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | LRSAM1 |
| Protein name | E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) Leucine rich repeat and sterile alpha motif containing 1 |
| Synonyms | UNQ6496/PRO21356 TAL |
| Description | FUNCTION: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos . Bacterial recognition protein that defends the cytoplasm from invasive pathogens . Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) . . |
| Accessions | ENST00000675641.1 ENST00000675224.1 A0A6Q8PGZ2 A0A6Q8PFI6 A0A6Q8PGF7 ENST00000675445.1 A0A6Q8PGB2 ENST00000676349.1 ENST00000300417.11 [Q6UWE0-1] ENST00000675789.1 ENST00000676014.1 ENST00000498513.6 ENST00000676336.1 ENST00000675572.1 ENST00000675448.1 [Q6UWE0-1] ENST00000323301.8 [Q6UWE0-1] ENST00000675253.1 A0A6Q8PF55 ENST00000373324.8 [Q6UWE0-2] A0A6Q8PFL1 A0A6Q8PG90 A0A6Q8PGT8 ENST00000675945.1 ENST00000675141.1 A0A6Q8PGW1 A0A6Q8PGH9 ENST00000674771.1 A0A6Q8PFW1 ENST00000472068.2 ENST00000373322.1 [Q6UWE0-1] ENST00000675657.1 ENST00000674970.1 Q6UWE0 ENST00000675883.1 [Q6UWE0-2] ENST00000674516.1 ENST00000676318.1 A0A6Q8PHH6 A0A6Q8PH70 A0A6Q8PEU7 A0A6Q8PFL5 A0A6Q8PFT9 A0A6Q8PG02 ENST00000675213.1 ENST00000676170.1 ENST00000674784.1 |
