LRRC8E report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LRRC8E at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LRRC8E at tissue level.

III. Associated gene sets

GO_0015810Biological processaspartate transmembrane transport
GO_0006884Biological processcell volume homeostasis
GO_0071470Biological processcellular response to osmotic stress
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0140361Biological processcyclic-GMP-AMP transmembrane import across plasma membrane
GO_0034702Cellular componentmonoatomic ion channel complex
GO_0005737Cellular componentcytoplasm
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005225Molecular functionvolume-sensitive anion channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLRRC8E
Protein nameVolume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E)
Leucine rich repeat containing 8 VRAC subunit E
Synonyms
DescriptionFUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine . Mediates efflux of amino acids, such as aspartate, in response to osmotic stress . The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol . Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition . Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis . .

AccessionsM0R2K8
ENST00000598224.5
ENST00000593511.1
M0R2D8
ENST00000599367.1
ENST00000306708.11
Q6NSJ5
M0R3C1
M0QZ48
ENST00000618098.4
ENST00000600345.1