LRRC8D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015810Biological processaspartate transmembrane transport
GO_0015734Biological processtaurine transmembrane transport
GO_0071470Biological processcellular response to osmotic stress
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0034214Biological processprotein hexamerization
GO_0001678Biological processintracellular glucose homeostasis
GO_0140361Biological processcyclic-GMP-AMP transmembrane import across plasma membrane
GO_0034702Cellular componentmonoatomic ion channel complex
GO_0005737Cellular componentcytoplasm
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005225Molecular functionvolume-sensitive anion channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLRRC8D
Protein nameVolume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D)
Leucine rich repeat containing 8 VRAC subunit D
LRRC8D protein
SynonymsLRRC5
UNQ213/PRO239
DescriptionFUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine . Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress . LRRC8A and LRRC8D are required for the uptake of the drug cisplatin . Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition . Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol . Mediates the import of the antibiotic blasticidin-S into the cell . .

AccessionsE9PJS7
ENST00000414841.1
ENST00000441269.2
E9PL08
ENST00000527156.1
ENST00000394593.7
ENST00000337338.9
Q96GG5
ENST00000532201.5
Q5VWA0
Q7L1W4
ENST00000525774.5
E9PMF9
E9PJ89