LRRC8C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015810Biological processaspartate transmembrane transport
GO_0015734Biological processtaurine transmembrane transport
GO_0071470Biological processcellular response to osmotic stress
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0034214Biological processprotein hexamerization
GO_0140361Biological processcyclic-GMP-AMP transmembrane import across plasma membrane
GO_0045444Biological processfat cell differentiation
GO_0034702Cellular componentmonoatomic ion channel complex
GO_0005737Cellular componentcytoplasm
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005225Molecular functionvolume-sensitive anion channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLRRC8C
Protein nameVolume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C)
LRRC8C protein
Leucine rich repeat containing 8 VRAC subunit C
SynonymsFAD158
AD158
DescriptionFUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine . Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress . The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol . Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition . .

AccessionsENST00000482063.1
E9PHY6
ENST00000370454.9
Q8TDW0
Q4G0W7