Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 12 studies | 37% ± 9% | |
glutamatergic neuron | 11 studies | 44% ± 22% | |
GABAergic neuron | 9 studies | 45% ± 24% | |
adipocyte | 7 studies | 21% ± 3% | |
oligodendrocyte precursor cell | 7 studies | 23% ± 8% | |
endothelial cell | 6 studies | 27% ± 9% | |
neuron | 5 studies | 28% ± 8% | |
interneuron | 5 studies | 49% ± 23% | |
microglial cell | 4 studies | 19% ± 1% | |
epithelial cell | 4 studies | 24% ± 8% | |
astrocyte | 4 studies | 20% ± 5% | |
GABAergic interneuron | 3 studies | 45% ± 5% | |
retinal cone cell | 3 studies | 23% ± 2% | |
ciliated cell | 3 studies | 19% ± 3% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 15 studies | 35% ± 21% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 99% | 1383.56 | 575 / 578 | 100% | 14.12 | 1154 / 1155 |
breast | 100% | 1285.08 | 459 / 459 | 99% | 13.72 | 1111 / 1118 |
adrenal gland | 100% | 3366.84 | 258 / 258 | 97% | 7.73 | 223 / 230 |
pancreas | 98% | 781.75 | 322 / 328 | 98% | 8.45 | 175 / 178 |
prostate | 96% | 817.04 | 235 / 245 | 100% | 14.43 | 501 / 502 |
thymus | 99% | 840.94 | 648 / 653 | 96% | 6.40 | 580 / 605 |
brain | 95% | 2403.47 | 2509 / 2642 | 100% | 17.37 | 704 / 705 |
stomach | 94% | 624.47 | 336 / 359 | 98% | 10.11 | 279 / 286 |
intestine | 93% | 700.40 | 895 / 966 | 98% | 9.17 | 515 / 527 |
uterus | 91% | 559.96 | 155 / 170 | 98% | 10.51 | 450 / 459 |
skin | 97% | 1206.20 | 1758 / 1809 | 92% | 9.31 | 433 / 472 |
bladder | 90% | 468.48 | 19 / 21 | 97% | 9.02 | 487 / 504 |
ovary | 88% | 498.87 | 158 / 180 | 99% | 7.46 | 424 / 430 |
esophagus | 85% | 683.65 | 1225 / 1445 | 99% | 16.02 | 182 / 183 |
kidney | 93% | 591.73 | 83 / 89 | 90% | 4.80 | 813 / 901 |
liver | 56% | 339.38 | 127 / 226 | 52% | 3.15 | 213 / 406 |
spleen | 100% | 765.13 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 14.46 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.20 | 1 / 1 |
adipose | 100% | 1175.29 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 88% | 815.93 | 708 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 4.83 | 25 / 29 |
heart | 79% | 469.98 | 679 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 48% | 2.14 | 38 / 80 |
blood vessel | 47% | 290.05 | 624 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 36% | 274.49 | 332 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0015810 | Biological process | aspartate transmembrane transport |
GO_0098656 | Biological process | monoatomic anion transmembrane transport |
GO_0140361 | Biological process | cyclic-GMP-AMP transmembrane import across plasma membrane |
GO_0034702 | Cellular component | monoatomic ion channel complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0005886 | Cellular component | plasma membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005225 | Molecular function | volume-sensitive anion channel activity |
GO_0005515 | Molecular function | protein binding |
Gene name | LRRC8B |
Protein name | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) LRRC8B protein Leucine rich repeat containing 8 VRAC subunit B |
Synonyms | KIAA0231 UNQ6413/PRO21207 |
Description | FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition . . |
Accessions | ENST00000439853.6 C9JGJ7 ENST00000449440.5 ENST00000640258.1 Q49AH5 ENST00000330947.7 ENST00000639264.1 Q6P9F7 A0A7I2RK03 |