LRRC8B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015810Biological processaspartate transmembrane transport
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0140361Biological processcyclic-GMP-AMP transmembrane import across plasma membrane
GO_0034702Cellular componentmonoatomic ion channel complex
GO_0005737Cellular componentcytoplasm
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005225Molecular functionvolume-sensitive anion channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLRRC8B
Protein nameVolume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP)
LRRC8B protein
Leucine rich repeat containing 8 VRAC subunit B
SynonymsKIAA0231
UNQ6413/PRO21207
DescriptionFUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition . .

AccessionsENST00000439853.6
C9JGJ7
ENST00000449440.5
ENST00000640258.1
Q49AH5
ENST00000330947.7
ENST00000639264.1
Q6P9F7
A0A7I2RK03