LRRC19 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LRRC19 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LRRC19 at tissue level.

III. Associated gene sets

GO_0002224Biological processtoll-like receptor signaling pathway
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0048874Biological processhost-mediated regulation of intestinal microbiota composition
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0050727Biological processregulation of inflammatory response
GO_0032637Biological processinterleukin-8 production
GO_0001817Biological processregulation of cytokine production
GO_0005886Cellular componentplasma membrane
GO_0038023Molecular functionsignaling receptor activity

IV. Literature review

[source]
Gene nameLRRC19
Protein nameLeucine-rich repeat-containing protein 19
Synonyms
DescriptionFUNCTION: Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines . In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances. In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (By similarity). .

AccessionsENST00000380055.6
Q9H756