LRIT3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LRIT3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LRIT3 at tissue level.

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0040036Biological processregulation of fibroblast growth factor receptor signaling pathway
GO_0043204Cellular componentperikaryon
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030425Cellular componentdendrite

IV. Literature review

[source]
Gene nameLRIT3
Protein nameLeucine rich repeat, Ig-like and transmembrane domains 3
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
Synonyms
DescriptionFUNCTION: Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (By similarity). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina . Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (By similarity). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (By similarity). May also have a role in cone synapse formation (By similarity). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi . Could be a regulator of the FGFRs . .

AccessionsENST00000594814.6 [Q3SXY7-1]
ENST00000327908.3
Q3SXY7
A0A0A0MR64