LRCH4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034123Biological processpositive regulation of toll-like receptor signaling pathway
GO_0007399Biological processnervous system development
GO_0001765Biological processmembrane raft assembly
GO_0005886Cellular componentplasma membrane
GO_0016605Cellular componentPML body
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLRCH4
Protein nameLeucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein)
Leucine rich repeats and calponin homology domain containing 4 (Leucine-rich repeats and calponin homology (CH) domain containing 4, isoform CRA_b)
SynonymsLRRN4
LRN
hCG_1794446
LRRN1
DescriptionFUNCTION: Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. .

AccessionsH7C5D9
ENST00000310300.11
O75427
ENST00000485554.6