LNX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0005737Cellular componentcytoplasm
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0030165Molecular functionPDZ domain binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameLNX1
Protein nameLigand of numb-protein X 1
E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)
SynonymsUNQ574/PRO1136
LNX
PDZRN2
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. .; FUNCTION: Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. .

AccessionsD6RAH9
ENST00000306888.6 [Q8TBB1-2]
A0A0B4J209
ENST00000510143.1
ENST00000512247.5
ENST00000513421.5
ENST00000507168.5
Q8TBB1
ENST00000263925.8 [Q8TBB1-1]
D6RB76
D6RE08