LMTK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006468Biological processprotein phosphorylation
GO_0005575Cellular componentcellular_component
GO_0000139Cellular componentGolgi membrane
GO_0030424Cellular componentaxon
GO_0030425Cellular componentdendrite
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0003674Molecular functionmolecular_function
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene nameLMTK3
Protein nameLemur tyrosine kinase 3
Serine/threonine-protein kinase LMTK3 (EC 2.7.11.1) (Lemur tyrosine kinase 3)
SynonymsKIAA1883
TYKLM3
DescriptionFUNCTION: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription . Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity). .

AccessionsENST00000673139.1
A0A3B3ITQ7
A0A3B3ISL5
Q96Q04
A0A3B3IRV9
ENST00000648216.1
A0A5F9ZHT0
ENST00000598924.1
ENST00000672160.1
ENST00000650440.1
ENST00000600059.6
A0A5F9ZH67
ENST00000647709.2