LIPT1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LIPT1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LIPT1 at tissue level.

III. Associated gene sets

GO_0036211Biological processprotein modification process
GO_0006629Biological processlipid metabolic process
GO_0009249Biological processprotein lipoylation
GO_0019752Biological processcarboxylic acid metabolic process
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0016746Molecular functionacyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0017118Molecular functionlipoyltransferase activity

IV. Literature review

[source]
Gene nameLIPT1
Protein nameLipoyltransferase 1
Lipoyl amidotransferase LIPT1, mitochondrial (EC 2.3.1.200) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase) (Lipoyltransferase 1) (EC 2.3.1.-)
Synonyms
DescriptionFUNCTION: Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl-GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2) . Unable to catalyze the transfer of octanoyl from octanoyl-GCSH to PDCE2 . In vitro, it is also able to catalyze the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes but this reaction may not be physiologically relevant (Probable). .

AccessionsENST00000415142.1
ENST00000393473.6
ENST00000436234.1
Q9Y234
C9J6A9
C9JW10
ENST00000393471.2
C9JUU5
ENST00000434566.5
ENST00000651691.1
ENST00000449211.1
C9J7C5