LIPE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008203Biological processcholesterol metabolic process
GO_0046340Biological processdiacylglycerol catabolic process
GO_0016042Biological processlipid catabolic process
GO_0019433Biological processtriglyceride catabolic process
GO_0042572Biological processretinol metabolic process
GO_0006468Biological processprotein phosphorylation
GO_0046485Biological processether lipid metabolic process
GO_0005811Cellular componentlipid droplet
GO_0016020Cellular componentmembrane
GO_0005901Cellular componentcaveola
GO_0005829Cellular componentcytosol
GO_0004806Molecular functiontriglyceride lipase activity
GO_0033878Molecular functionhormone-sensitive lipase activity
GO_0047376Molecular functionall-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
GO_0004771Molecular functionsterol esterase activity
GO_0102259Molecular function1,2-diacylglycerol acylhydrolase activity
GO_0050253Molecular functionretinyl-palmitate esterase activity
GO_0047372Molecular functionacylglycerol lipase activity
GO_0102258Molecular function1,3-diacylglycerol acylhydrolase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLIPE
Protein nameLipase E, hormone sensitive type
Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH)
Synonyms
DescriptionFUNCTION: Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters . Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs . Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity). .

AccessionsENST00000244289.9 [Q05469-1]
ENST00000599211.1
M0QXB1
ENST00000599783.5
ENST00000601189.1
ENST00000597620.5
M0R2G1
ENST00000599918.1
ENST00000597001.1
M0QYP8
M0QXM5
Q05469
M0R201
M0QY29