LIN54 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034728Biological processnucleosome organization
GO_0006355Biological processregulation of DNA-templated transcription
GO_0090571Cellular componentRNA polymerase II transcription repressor complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003680Molecular functionminor groove of adenine-thymine-rich DNA binding
GO_0001067Molecular functiontranscription regulatory region nucleic acid binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameLIN54
Protein nameLin-54 DREAM MuvB core complex component
Protein lin-54 homolog (CXC domain-containing protein 1)
SynonymsKIAA2037
CXCDC1
DescriptionFUNCTION: Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context . In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes . In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation . In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner . Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA . .

AccessionsENST00000506560.5 [Q6MZP7-2]
ENST00000508171.5 [Q6MZP7-5]
ENST00000510557.5 [Q6MZP7-3]
ENST00000510877.5
ENST00000505397.1 [Q6MZP7-1]
ENST00000446851.6 [Q6MZP7-3]
ENST00000442461.6 [Q6MZP7-3]
ENST00000340417.8 [Q6MZP7-1]
D6REW4
Q6MZP7