LILRA3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LILRA3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LILRA3 at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0002764Biological processimmune response-regulating signaling pathway
GO_0140105Biological processinterleukin-10-mediated signaling pathway
GO_0070821Cellular componenttertiary granule membrane
GO_0005576Cellular componentextracellular region
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0032396Molecular functioninhibitory MHC class I receptor activity

IV. Literature review

[source]
Gene nameLILRA3
Protein nameLeukocyte immunoglobulin-like receptor subfamily A member 3
LILRA3 protein
Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e)
Leukocyte immunoglobulin-like receptor A3
SynonymsILT6
LIR4
DescriptionFUNCTION: Acts as a soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. .

AccessionsA0A0G2JLV5
ENST00000620589.4 [Q8N6C8-1]
ENST00000615416.2
ENST00000619928.1
ENST00000619618.4
ENST00000613983.4
ENST00000620042.4
ENST00000615652.4 [Q8N6C8-1]
Q8NHJ5
A0A0G2JM97
ENST00000610381.1
ENST00000617121.1
ENST00000615584.4
ENST00000610305.4
ENST00000612127.4 [Q8N6C8-1]
ENST00000619638.4 [Q8N6C8-1]
H2B4M3
A0A0G2JM99
A0A0G2JMJ0
H2B4M4
A0A0G2JMY9
ENST00000611439.4
ENST00000613018.4
Q8N6C8
ENST00000616964.3
ENST00000617541.4 [Q8N6C8-2]