LETM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0140141Biological processmitochondrial potassium ion transmembrane transport
GO_0007007Biological processinner mitochondrial membrane organization
GO_0051562Biological processnegative regulation of mitochondrial calcium ion concentration
GO_0051560Biological processmitochondrial calcium ion homeostasis
GO_0042407Biological processcristae formation
GO_0034214Biological processprotein hexamerization
GO_0030003Biological processintracellular monoatomic cation homeostasis
GO_1900069Biological processregulation of cellular hyperosmotic salinity response
GO_0099093Biological processcalcium export from the mitochondrion
GO_0006851Biological processmitochondrial calcium ion transmembrane transport
GO_0006816Biological processcalcium ion transport
GO_1902600Biological processproton transmembrane transport
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0043022Molecular functionribosome binding
GO_0015369Molecular functioncalcium:proton antiporter activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLETM1
Protein nameMitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1)
Synonyms
DescriptionFUNCTION: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport . Mediates proton-dependent calcium efflux from mitochondrion . Functions also as an electroneutral mitochondrial proton/potassium exchanger . Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain . Required for the maintenance of the tubular shape and cristae organization . .

AccessionsENST00000302787.3 [O95202-1]
O95202