Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 6 studies | 29% ± 6% | |
| glutamatergic neuron | 4 studies | 29% ± 12% | |
| basal cell | 4 studies | 23% ± 6% | |
| endothelial cell | 3 studies | 20% ± 3% | |
| GABAergic neuron | 3 studies | 25% ± 7% | |
| astrocyte | 3 studies | 18% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3535.53 | 1445 / 1445 | 100% | 33.98 | 183 / 183 |
| intestine | 100% | 3802.68 | 966 / 966 | 100% | 32.76 | 527 / 527 |
| prostate | 100% | 2486.00 | 245 / 245 | 100% | 23.73 | 502 / 502 |
| skin | 100% | 3984.62 | 1809 / 1809 | 100% | 33.65 | 472 / 472 |
| uterus | 100% | 2327.74 | 170 / 170 | 100% | 26.43 | 459 / 459 |
| breast | 100% | 3127.51 | 459 / 459 | 100% | 34.95 | 1117 / 1118 |
| brain | 100% | 2842.10 | 2638 / 2642 | 100% | 29.36 | 705 / 705 |
| bladder | 100% | 2398.33 | 21 / 21 | 100% | 29.32 | 503 / 504 |
| liver | 100% | 2421.22 | 226 / 226 | 100% | 17.19 | 405 / 406 |
| pancreas | 100% | 1937.87 | 327 / 328 | 100% | 21.75 | 178 / 178 |
| thymus | 100% | 3274.89 | 653 / 653 | 100% | 27.26 | 603 / 605 |
| stomach | 100% | 2948.84 | 359 / 359 | 100% | 29.70 | 285 / 286 |
| lung | 100% | 2637.62 | 578 / 578 | 100% | 25.89 | 1150 / 1155 |
| kidney | 100% | 3234.44 | 89 / 89 | 99% | 18.11 | 895 / 901 |
| adrenal gland | 100% | 4250.92 | 258 / 258 | 99% | 18.99 | 228 / 230 |
| ovary | 100% | 2491.71 | 180 / 180 | 99% | 21.37 | 426 / 430 |
| adipose | 100% | 3254.13 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 25.09 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 28.46 | 29 / 29 |
| muscle | 100% | 2906.93 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2961.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 29.47 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 21.17 | 1 / 1 |
| blood vessel | 100% | 1780.00 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 2927.27 | 850 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 70% | 1472.03 | 649 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0051260 | Biological process | protein homooligomerization |
| GO_0140141 | Biological process | mitochondrial potassium ion transmembrane transport |
| GO_0007007 | Biological process | inner mitochondrial membrane organization |
| GO_0051562 | Biological process | negative regulation of mitochondrial calcium ion concentration |
| GO_0051560 | Biological process | mitochondrial calcium ion homeostasis |
| GO_0042407 | Biological process | cristae formation |
| GO_0034214 | Biological process | protein hexamerization |
| GO_0030003 | Biological process | intracellular monoatomic cation homeostasis |
| GO_1900069 | Biological process | regulation of cellular hyperosmotic salinity response |
| GO_0099093 | Biological process | calcium export from the mitochondrion |
| GO_0006851 | Biological process | mitochondrial calcium ion transmembrane transport |
| GO_0006816 | Biological process | calcium ion transport |
| GO_1902600 | Biological process | proton transmembrane transport |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0043022 | Molecular function | ribosome binding |
| GO_0015369 | Molecular function | calcium:proton antiporter activity |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | LETM1 |
| Protein name | Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1) |
| Synonyms | |
| Description | FUNCTION: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport . Mediates proton-dependent calcium efflux from mitochondrion . Functions also as an electroneutral mitochondrial proton/potassium exchanger . Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain . Required for the maintenance of the tubular shape and cristae organization . . |
| Accessions | ENST00000302787.3 [O95202-1] O95202 |
