LCMT2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LCMT2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LCMT2 at tissue level.

III. Associated gene sets

GO_0031591Biological processwybutosine biosynthetic process
GO_0006400Biological processtRNA modification
GO_0030488Biological processtRNA methylation
GO_0005737Cellular componentcytoplasm
GO_0008175Molecular functiontRNA methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLCMT2
Protein nameLeucine carboxyl methyltransferase 2
tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase)
SynonymsTYW4
KIAA0547
DescriptionFUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. .

AccessionsENST00000567039.1
O60294
H3BU01
ENST00000305641.7