LCAT report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LCAT at tissue level.

III. Associated gene sets

GO_0042158Biological processlipoprotein biosynthetic process
GO_0034372Biological processvery-low-density lipoprotein particle remodeling
GO_0006656Biological processphosphatidylcholine biosynthetic process
GO_0008203Biological processcholesterol metabolic process
GO_0043691Biological processreverse cholesterol transport
GO_0034375Biological processhigh-density lipoprotein particle remodeling
GO_0046470Biological processphosphatidylcholine metabolic process
GO_0006644Biological processphospholipid metabolic process
GO_0090107Biological processregulation of high-density lipoprotein particle assembly
GO_0006629Biological processlipid metabolic process
GO_0030301Biological processcholesterol transport
GO_0042632Biological processcholesterol homeostasis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0034364Cellular componenthigh-density lipoprotein particle
GO_0004607Molecular functionphosphatidylcholine-sterol O-acyltransferase activity
GO_0004771Molecular functionsterol esterase activity
GO_0047179Molecular functionplatelet-activating factor acetyltransferase activity
GO_0003847Molecular function1-alkyl-2-acetylglycerophosphocholine esterase activity
GO_0034186Molecular functionapolipoprotein A-I binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLCAT
Protein namePhosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase)
Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (1-alkyl-2-acetylglycerophosphocholine esterase) (EC 3.1.1.47) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase)
Lecithin-cholesterol acyltransferase (EC 2.3.1.43)
Lecithin-cholesterol acyltransferase
Synonyms
DescriptionFUNCTION: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) . The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines . Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms . Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) . Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF . Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters . .

AccessionsJ3QKT0
ENST00000570980.1
ENST00000570369.5
P04180
I3L0J6
ENST00000576450.1
ENST00000575467.5
I3L215
ENST00000570396.1
J3QSE5
I3L3R0
I3L1Q6
ENST00000573538.5
Q9Y5N3
ENST00000264005.10