LARGE2 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of LARGE2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	2045.15	653 / 653	94%	29.19	569 / 605
prostate	89%	1789.94	217 / 245	99%	54.11	495 / 502
ovary	80%	291.81	144 / 180	98%	69.32	420 / 430
kidney	100%	1805.97	89 / 89	55%	13.49	499 / 901
stomach	75%	856.08	269 / 359	77%	42.83	220 / 286
lung	60%	237.87	345 / 578	86%	48.57	997 / 1155
pancreas	100%	1682.36	328 / 328	45%	8.96	80 / 178
esophagus	39%	757.71	557 / 1445	89%	51.66	162 / 183
breast	53%	471.25	245 / 459	70%	22.88	779 / 1118
bladder	43%	269.62	9 / 21	72%	35.62	363 / 504
intestine	20%	150.94	197 / 966	83%	41.91	435 / 527
uterus	19%	127.12	33 / 170	77%	33.93	352 / 459
spleen	86%	444.37	208 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	82%	39.97	37 / 45
skin	72%	1623.90	1305 / 1809	4%	1.20	21 / 472
adrenal gland	64%	236.34	166 / 258	8%	2.96	19 / 230
liver	39%	126.65	88 / 226	30%	7.40	122 / 406
peripheral blood	23%	94.65	211 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	0.66	2 / 29
adipose	2%	7.98	21 / 1204	0%	0	0 / 0
blood vessel	0%	5.72	6 / 1335	0%	0	0 / 0
brain	0%	0.33	3 / 2642	0%	0.06	1 / 705
heart	0%	0.56	2 / 861	0%	0	0 / 0
muscle	0%	0.31	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0046716	Biological process	muscle cell cellular homeostasis
GO_0006493	Biological process	protein O-linked glycosylation
GO_0035269	Biological process	protein O-linked mannosylation
GO_0000139	Cellular component	Golgi membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0030145	Molecular function	manganese ion binding
GO_0015020	Molecular function	glucuronosyltransferase activity
GO_0005515	Molecular function	protein binding
GO_0042285	Molecular function	xylosyltransferase activity
GO_0035252	Molecular function	UDP-xylosyltransferase activity

Gene name	LARGE2
Protein name	Alternative protein GYLTL1B Xylosyl- and glucuronyltransferase LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B) (LARGE xylosyl- and glucuronyltransferase 2) [Includes: Alpha-1,3-xylosyltransferase LARGE2 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE2 (EC 2.4.1.-)] LARGE xylosyl- and glucuronyltransferase 2
Synonyms	GYLTL1B PP5656
Description	FUNCTION: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner . Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 . In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity). .
Accessions	H0YDU6 ENST00000531526.5 ENST00000534410.1 ENST00000531847.1 ENST00000529052.5 H0YDB8 ENST00000401752.6 ENST00000325468.9 Q8N3Y3 E9PIZ2 L8E9M0

LARGE2 report