LACTB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019216Biological processregulation of lipid metabolic process
GO_0006629Biological processlipid metabolic process
GO_0006508Biological processproteolysis
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0008233Molecular functionpeptidase activity
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameLACTB
Protein nameLactamase beta
Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)
SynonymsMRPL56
UNQ843/PRO1781
DescriptionFUNCTION: Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism . Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism . It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein . Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism . .

AccessionsENST00000261893.9 [P83111-1]
P83111
H0YNN5
ENST00000413507.3 [P83111-2]
ENST00000557972.1