Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 29 studies | 33% ± 17% | |
non-classical monocyte | 18 studies | 32% ± 11% | |
classical monocyte | 17 studies | 31% ± 13% | |
dendritic cell | 16 studies | 39% ± 13% | |
monocyte | 14 studies | 36% ± 17% | |
conventional dendritic cell | 12 studies | 28% ± 11% | |
myeloid cell | 11 studies | 32% ± 14% | |
B cell | 10 studies | 23% ± 6% | |
memory B cell | 8 studies | 19% ± 3% | |
mononuclear phagocyte | 6 studies | 30% ± 13% | |
microglial cell | 6 studies | 28% ± 9% | |
alveolar macrophage | 5 studies | 42% ± 21% | |
plasmacytoid dendritic cell | 5 studies | 25% ± 8% | |
respiratory goblet cell | 4 studies | 38% ± 12% | |
squamous epithelial cell | 3 studies | 36% ± 22% | |
inflammatory macrophage | 3 studies | 42% ± 12% | |
hepatocyte | 3 studies | 65% ± 16% | |
monocyte-derived dendritic cell | 3 studies | 38% ± 16% | |
leukocyte | 3 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
lung | 5 studies | 26% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 2516.61 | 226 / 226 | 90% | 6.24 | 366 / 406 |
lung | 99% | 952.08 | 575 / 578 | 83% | 7.57 | 961 / 1155 |
breast | 95% | 409.48 | 434 / 459 | 64% | 4.27 | 718 / 1118 |
kidney | 93% | 461.19 | 83 / 89 | 62% | 1.57 | 556 / 901 |
bladder | 81% | 380.76 | 17 / 21 | 68% | 5.76 | 341 / 504 |
esophagus | 68% | 254.47 | 980 / 1445 | 76% | 5.56 | 139 / 183 |
thymus | 93% | 273.26 | 610 / 653 | 17% | 0.46 | 100 / 605 |
intestine | 63% | 157.21 | 610 / 966 | 40% | 1.36 | 211 / 527 |
uterus | 39% | 67.96 | 67 / 170 | 64% | 5.65 | 292 / 459 |
adrenal gland | 98% | 402.60 | 253 / 258 | 4% | 0.15 | 10 / 230 |
pancreas | 11% | 17.54 | 37 / 328 | 91% | 3.84 | 162 / 178 |
skin | 55% | 203.74 | 996 / 1809 | 46% | 1.78 | 215 / 472 |
lymph node | 0% | 0 | 0 / 0 | 100% | 8.97 | 29 / 29 |
spleen | 100% | 872.35 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.41 | 1 / 1 |
peripheral blood | 99% | 1390.00 | 924 / 929 | 0% | 0 | 0 / 0 |
adipose | 92% | 319.72 | 1104 / 1204 | 0% | 0 | 0 / 0 |
stomach | 44% | 98.59 | 158 / 359 | 45% | 1.87 | 130 / 286 |
tonsil | 0% | 0 | 0 / 0 | 82% | 6.49 | 37 / 45 |
blood vessel | 61% | 158.28 | 817 / 1335 | 0% | 0 | 0 / 0 |
prostate | 42% | 79.82 | 104 / 245 | 3% | 0.04 | 13 / 502 |
ovary | 13% | 17.54 | 24 / 180 | 23% | 0.41 | 98 / 430 |
brain | 17% | 25.77 | 440 / 2642 | 17% | 0.31 | 117 / 705 |
heart | 26% | 44.81 | 224 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 15% | 0.75 | 12 / 80 |
muscle | 1% | 1.59 | 10 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0019805 | Biological process | quinolinate biosynthetic process |
GO_0019441 | Biological process | tryptophan catabolic process to kynurenine |
GO_0034516 | Biological process | response to vitamin B6 |
GO_0097053 | Biological process | L-kynurenine catabolic process |
GO_0034341 | Biological process | response to type II interferon |
GO_0043420 | Biological process | anthranilate metabolic process |
GO_0009435 | Biological process | NAD biosynthetic process |
GO_0006569 | Biological process | tryptophan catabolic process |
GO_0034354 | Biological process | 'de novo' NAD biosynthetic process from tryptophan |
GO_0005737 | Cellular component | cytoplasm |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005739 | Cellular component | mitochondrion |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0061981 | Molecular function | 3-hydroxykynureninase activity |
GO_0030170 | Molecular function | pyridoxal phosphate binding |
GO_0030429 | Molecular function | kynureninase activity |
Gene name | KYNU |
Protein name | Uncharacterized protein KYNU Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) Kynureninase |
Synonyms | |
Description | FUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. . FUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. . FUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. . |
Accessions | ENST00000264170.9 [Q16719-1] A0A087WYM2 ENST00000424385.5 ENST00000409512.5 [Q16719-1] A8K7T0 A8K4D5 F8WEP1 ENST00000612147.4 ENST00000410015.6 B8ZZA3 A0A087X297 ENST00000375773.6 [Q16719-2] ENST00000613664.1 A0A087WYQ7 Q53SX6 Q53SY0 ENST00000621320.4 Q16719 |