KYNU report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019805Biological processquinolinate biosynthetic process
GO_0019441Biological processtryptophan catabolic process to kynurenine
GO_0034516Biological processresponse to vitamin B6
GO_0097053Biological processL-kynurenine catabolic process
GO_0034341Biological processresponse to type II interferon
GO_0043420Biological processanthranilate metabolic process
GO_0009435Biological processNAD biosynthetic process
GO_0006569Biological processtryptophan catabolic process
GO_0034354Biological process'de novo' NAD biosynthetic process from tryptophan
GO_0005737Cellular componentcytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0042803Molecular functionprotein homodimerization activity
GO_0061981Molecular function3-hydroxykynureninase activity
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0030429Molecular functionkynureninase activity

IV. Literature review

[source]
Gene nameKYNU
Protein nameUncharacterized protein KYNU
Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase)
Kynureninase
Synonyms
DescriptionFUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. .

FUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. .

FUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. .

AccessionsENST00000264170.9 [Q16719-1]
A0A087WYM2
ENST00000424385.5
ENST00000409512.5 [Q16719-1]
A8K7T0
A8K4D5
F8WEP1
ENST00000612147.4
ENST00000410015.6
B8ZZA3
A0A087X297
ENST00000375773.6 [Q16719-2]
ENST00000613664.1
A0A087WYQ7
Q53SX6
Q53SY0
ENST00000621320.4
Q16719