KYAT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006103Biological process2-oxoglutarate metabolic process
GO_0070189Biological processkynurenine metabolic process
GO_0097053Biological processL-kynurenine catabolic process
GO_0009058Biological processbiosynthetic process
GO_0006520Biological processamino acid metabolic process
GO_0005739Cellular componentmitochondrion
GO_0005737Cellular componentcytoplasm
GO_0016212Molecular functionkynurenine-oxoglutarate transaminase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0047804Molecular functioncysteine-S-conjugate beta-lyase activity
GO_0047315Molecular functionkynurenine-glyoxylate transaminase activity
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameKYAT3
Protein nameAlternative protein CCBL2
Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.63) (EC 2.6.1.7) (EC 4.4.1.13) (Cysteine-S-conjugate beta-lyase 2) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (Kynurenine--glyoxylate transaminase) (Kynurenine--oxoglutarate transaminase III)
Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III)
SynonymsKAT3
CCBL2
DescriptionFUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). .

AccessionsENST00000370491.7 [Q6YP21-3]
ENST00000370486.1
ENST00000260508.9 [Q6YP21-1]
Q6YP21
L0R594
A0A0A0MRN7