I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 5 studies | 34% ± 19% | |
| astrocyte | 5 studies | 25% ± 6% | |
| glutamatergic neuron | 4 studies | 42% ± 21% | |
| interneuron | 3 studies | 37% ± 22% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 5 studies | 34% ± 19% | |
| astrocyte | 5 studies | 25% ± 6% | |
| glutamatergic neuron | 4 studies | 42% ± 21% | |
| interneuron | 3 studies | 37% ± 22% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 34% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1126.59 | 2640 / 2642 | 6% | 0.08 | 42 / 705 |
| esophagus | 100% | 494.31 | 1443 / 1445 | 4% | 0.06 | 8 / 183 |
| stomach | 100% | 453.30 | 359 / 359 | 2% | 0.03 | 6 / 286 |
| thymus | 100% | 819.80 | 653 / 653 | 1% | 0.02 | 6 / 605 |
| bladder | 100% | 856.19 | 21 / 21 | 1% | 0.01 | 4 / 504 |
| ovary | 100% | 732.05 | 180 / 180 | 1% | 0.01 | 3 / 430 |
| kidney | 100% | 761.04 | 89 / 89 | 1% | 0.01 | 6 / 901 |
| uterus | 100% | 782.78 | 170 / 170 | 0% | 0.01 | 2 / 459 |
| prostate | 100% | 961.73 | 245 / 245 | 0% | 0.01 | 2 / 502 |
| blood vessel | 100% | 779.96 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| liver | 100% | 766.08 | 226 / 226 | 0% | 0 | 0 / 406 |
| spleen | 100% | 635.75 | 241 / 241 | 0% | 0 | 0 / 0 |
| skin | 100% | 585.36 | 1808 / 1809 | 0% | 0 | 0 / 472 |
| muscle | 100% | 543.82 | 802 / 803 | 0% | 0 | 0 / 0 |
| breast | 99% | 450.29 | 454 / 459 | 1% | 0.02 | 10 / 1118 |
| lung | 99% | 447.66 | 571 / 578 | 1% | 0.02 | 11 / 1155 |
| intestine | 99% | 463.18 | 952 / 966 | 1% | 0.01 | 4 / 527 |
| adrenal gland | 99% | 479.45 | 256 / 258 | 0% | 0 | 0 / 230 |
| adipose | 98% | 384.20 | 1182 / 1204 | 0% | 0 | 0 / 0 |
| heart | 97% | 666.54 | 836 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 91% | 371.36 | 841 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 84% | 192.67 | 277 / 328 | 1% | 0.01 | 2 / 178 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0097053 | Biological process | L-kynurenine catabolic process |
| GO_0070189 | Biological process | kynurenine metabolic process |
| GO_0009058 | Biological process | biosynthetic process |
| GO_0009617 | Biological process | response to bacterium |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0016212 | Molecular function | kynurenine-oxoglutarate transaminase activity |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0047804 | Molecular function | cysteine-S-conjugate beta-lyase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0047316 | Molecular function | glutamine-phenylpyruvate transaminase activity |
| GO_0030170 | Molecular function | pyridoxal phosphate binding |
| Gene name | KYAT1 |
| Protein name | Cysteine conjugate-beta lyase cytoplasmic (Glutamine transaminase K, kyneurenine aminotransferase), isoform CRA_a (cDNA FLJ77833, highly similar to H.sapiens glutamine transaminase K) (cDNA, FLJ95217, Homo sapiens cysteine conjugate-beta lyase; cytoplasmic (glutaminetransaminase K, kyneurenine aminotransferase) (CCBL1), mRNA) Cysteine conjugate-beta lyase cytoplasmic (Glutamine transaminase K, kyneurenine aminotransferase), isoform CRA_b (Kynurenine aminotransferase 1) (cDNA FLJ56468, highly similar to Kynurenine--oxoglutarate transaminase 1) kynurenine--oxoglutarate transaminase (EC 2.6.1.7) Kynurenine aminotransferase 1 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) Cysteine conjugate beta-lyase Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase 1) (Kynurenine aminotransferase I) (KATI) (Kynurenine--oxoglutarate transaminase I) |
| Synonyms | hCG_30593 CCBL1 |
| Description | FUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others . Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites . Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond . . |
| Accessions | ENST00000302586.8 [Q16773-1] ENST00000436267.7 B7Z4W5 ENST00000416084.5 Q9UQN6 Q9UQN7 Q5T276 A0A494C066 ENST00000320665.10 [Q16773-2] ENST00000427720.1 Q16773 A8K563 Q5T277 ENST00000451800.5 ENST00000651925.1 Q5T278 |
