I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 17% ± 1% |
Insufficient scRNA-seq data for expression of KNSTRN at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 315.16 | 180 / 180 | 100% | 19.03 | 428 / 430 |
| stomach | 100% | 542.64 | 358 / 359 | 100% | 17.92 | 285 / 286 |
| thymus | 100% | 4347.28 | 653 / 653 | 99% | 24.22 | 600 / 605 |
| breast | 100% | 408.85 | 457 / 459 | 99% | 19.33 | 1111 / 1118 |
| bladder | 100% | 324.14 | 21 / 21 | 99% | 20.43 | 497 / 504 |
| prostate | 100% | 491.23 | 244 / 245 | 99% | 13.93 | 497 / 502 |
| intestine | 100% | 407.15 | 966 / 966 | 98% | 18.87 | 519 / 527 |
| uterus | 99% | 359.81 | 169 / 170 | 99% | 26.14 | 454 / 459 |
| esophagus | 99% | 414.94 | 1434 / 1445 | 99% | 22.65 | 181 / 183 |
| lung | 98% | 462.85 | 568 / 578 | 99% | 20.80 | 1147 / 1155 |
| skin | 100% | 892.83 | 1804 / 1809 | 98% | 17.13 | 461 / 472 |
| brain | 98% | 486.46 | 2591 / 2642 | 99% | 14.21 | 698 / 705 |
| liver | 98% | 315.08 | 222 / 226 | 88% | 9.29 | 356 / 406 |
| pancreas | 89% | 194.29 | 293 / 328 | 93% | 10.04 | 166 / 178 |
| kidney | 100% | 342.89 | 89 / 89 | 82% | 5.86 | 741 / 901 |
| adrenal gland | 100% | 436.60 | 257 / 258 | 80% | 7.81 | 185 / 230 |
| spleen | 100% | 512.31 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 27.27 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.39 | 1 / 1 |
| muscle | 100% | 486.64 | 799 / 803 | 0% | 0 | 0 / 0 |
| adipose | 99% | 403.01 | 1196 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 97% | 270.78 | 1294 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 17.99 | 28 / 29 |
| peripheral blood | 92% | 684.16 | 853 / 929 | 0% | 0 | 0 / 0 |
| heart | 91% | 306.05 | 784 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 80% | 7.05 | 64 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0000070 | Biological process | mitotic sister chromatid segregation |
| GO_0071364 | Biological process | cellular response to epidermal growth factor stimulus |
| GO_0051988 | Biological process | regulation of attachment of spindle microtubules to kinetochore |
| GO_0051301 | Biological process | cell division |
| GO_0000226 | Biological process | microtubule cytoskeleton organization |
| GO_0016477 | Biological process | cell migration |
| GO_0007051 | Biological process | spindle organization |
| GO_0001726 | Cellular component | ruffle |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0034451 | Cellular component | centriolar satellite |
| GO_0000922 | Cellular component | spindle pole |
| GO_0072686 | Cellular component | mitotic spindle |
| GO_0000776 | Cellular component | kinetochore |
| GO_0005815 | Cellular component | microtubule organizing center |
| GO_0035371 | Cellular component | microtubule plus-end |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0051010 | Molecular function | microtubule plus-end binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KNSTRN |
| Protein name | Kinetochore localized astrin (SPAG5) binding protein Chromosome 15 open reading frame 23, isoform CRA_d (Kinetochore localized astrin (SPAG5) binding protein) Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) |
| Synonyms | TRAF4AF1 SKAP C15orf23 hCG_38973 HSD11 |
| Description | FUNCTION: Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase . Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture . The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments . Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division . May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences . . |
| Accessions | ENST00000557920.1 ENST00000448395.6 [Q9Y448-3] H0YKD4 H0YKF8 H0YNN6 ENST00000560981.5 Q9Y448 ENST00000560321.5 ENST00000560220.5 H0YLH8 ENST00000416151.6 [Q9Y448-2] H0YN50 H0YLA7 H0YM11 ENST00000561169.5 ENST00000249776.13 [Q9Y448-1] ENST00000559304.5 ENST00000608100.5 V9GY01 ENST00000559083.1 |
