KNL1 | OmnibusX

Name	Number of supported studies	Average coverage
transit amplifying cell	3 studies	40% ± 14%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of KNL1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	93%	982.32	1679 / 1809	80%	5.19	379 / 472
lung	89%	162.94	514 / 578	81%	5.85	935 / 1155
liver	92%	232.73	208 / 226	72%	3.79	291 / 406
intestine	57%	248.56	554 / 966	94%	7.58	494 / 527
stomach	53%	140.10	192 / 359	94%	8.51	268 / 286
esophagus	46%	247.68	668 / 1445	99%	13.90	182 / 183
bladder	33%	33.29	7 / 21	87%	6.59	439 / 504
breast	39%	37.69	178 / 459	81%	5.46	911 / 1118
uterus	14%	16.32	24 / 170	96%	9.60	439 / 459
kidney	93%	198.56	83 / 89	15%	0.59	137 / 901
spleen	100%	320.07	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.46	1 / 1
tonsil	0%	0	0 / 0	98%	11.35	44 / 45
lymph node	0%	0	0 / 0	90%	9.17	26 / 29
thymus	70%	62.16	455 / 653	14%	1.57	87 / 605
pancreas	13%	11.52	42 / 328	66%	2.97	118 / 178
ovary	20%	30.07	36 / 180	58%	2.32	251 / 430
adrenal gland	56%	64.24	144 / 258	13%	0.57	29 / 230
peripheral blood	65%	1034.98	608 / 929	0%	0	0 / 0
prostate	36%	34.07	89 / 245	8%	0.28	42 / 502
brain	2%	2.10	56 / 2642	42%	2.48	294 / 705
adipose	43%	48.33	515 / 1204	0%	0	0 / 0
blood vessel	24%	22.51	320 / 1335	0%	0	0 / 0
heart	17%	17.52	146 / 861	0%	0	0 / 0
muscle	2%	1.32	13 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.03	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0034501	Biological process	protein localization to kinetochore
GO_1905326	Biological process	positive regulation of meiosis I spindle assembly checkpoint
GO_0008608	Biological process	attachment of spindle microtubules to kinetochore
GO_0051301	Biological process	cell division
GO_0031619	Biological process	homologous chromosome orientation in meiotic metaphase I
GO_0001675	Biological process	acrosome assembly
GO_0090266	Biological process	regulation of mitotic cell cycle spindle assembly checkpoint
GO_0000070	Biological process	mitotic sister chromatid segregation
GO_0000776	Cellular component	kinetochore
GO_0180019	Cellular component	Knl1/Spc105 complex
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0001669	Cellular component	acrosomal vesicle
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

Gene name	KNL1
Protein name	Kinetochore scaffold 1 CASC5 protein Kinetochore scaffold 1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14)
Synonyms	CASC5 KIAA1570
Description	FUNCTION: Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. .
Accessions	ENST00000399668.7 [Q8NG31-2] ENST00000528975.5 A0A1Y8EIW7 ENST00000346991.9 [Q8NG31-1] ENST00000526913.5 H0YEY7 H0YCZ2 ENST00000534204.1 Q05C46 ENST00000532406.1 A0A0G2JL96 Q8NG31 H0YN41 ENST00000532056.5

KNL1 report