KMT5C report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KMT5C at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KMT5C at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0032259Biological processmethylation
GO_0006338Biological processchromatin remodeling
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0045830Biological processpositive regulation of isotype switching
GO_0000792Cellular componentheterochromatin
GO_0005654Cellular componentnucleoplasm
GO_0005721Cellular componentpericentric heterochromatin
GO_0000779Cellular componentcondensed chromosome, centromeric region
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0140939Molecular functionhistone H4 methyltransferase activity
GO_0140944Molecular functionhistone H4K20 monomethyltransferase activity
GO_0140941Molecular functionhistone H4K20me methyltransferase activity
GO_0042799Molecular functionhistone H4K20 methyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKMT5C
Protein name[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B (EC 2.1.1.361) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B)
Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361)
SynonymsSUV420H2
hCG_38236
PP7130
DescriptionFUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity . In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes . H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 . May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). .

AccessionsA0A0D9SF94
ENST00000255613.8 [Q86Y97-1]
ENST00000592631.5 [Q86Y97-2]
Q86Y97
ENST00000630497.1
ENST00000445196.5 [Q86Y97-2]