KMO report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KMO at tissue level.

III. Associated gene sets

GO_0019805Biological processquinolinate biosynthetic process
GO_0097052Biological processL-kynurenine metabolic process
GO_0009651Biological processresponse to salt stress
GO_1903296Biological processpositive regulation of glutamate secretion, neurotransmission
GO_0070189Biological processkynurenine metabolic process
GO_0071347Biological processcellular response to interleukin-1
GO_0006569Biological processtryptophan catabolic process
GO_0034354Biological process'de novo' NAD biosynthetic process from tryptophan
GO_0019674Biological processNAD metabolic process
GO_0043420Biological processanthranilate metabolic process
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0034276Biological processkynurenic acid biosynthetic process
GO_0005615Cellular componentextracellular space
GO_0005829Cellular componentcytosol
GO_0005741Cellular componentmitochondrial outer membrane
GO_0050660Molecular functionflavin adenine dinucleotide binding
GO_0071949Molecular functionFAD binding
GO_0004502Molecular functionkynurenine 3-monooxygenase activity
GO_0016174Molecular functionNAD(P)H oxidase H2O2-forming activity

IV. Literature review

[source]
Gene nameKMO
Protein nameKynurenine 3-monooxygenase
Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase)
Synonyms
DescriptionFUNCTION: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) . Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). .

FUNCTION: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. .

FUNCTION: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. .

AccessionsA8K693
O15229
ENST00000366558.7 [O15229-2]
ENST00000366555.5
Q9BS61
H0Y320
ENST00000366559.9 [O15229-1]
ENST00000366557.8 [O15229-3]