I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 46% ± 18% | |
| astrocyte | 4 studies | 36% ± 8% | |
| GABAergic neuron | 3 studies | 23% ± 4% | |
| glutamatergic neuron | 3 studies | 22% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 46% ± 18% | |
| astrocyte | 4 studies | 36% ± 8% | |
| GABAergic neuron | 3 studies | 23% ± 4% | |
| glutamatergic neuron | 3 studies | 22% ± 6% |
Insufficient scRNA-seq data for expression of KLKB1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 6507.40 | 226 / 226 | 99% | 73.30 | 403 / 406 |
| kidney | 100% | 617.01 | 89 / 89 | 79% | 4.62 | 716 / 901 |
| pancreas | 100% | 350.35 | 327 / 328 | 67% | 2.93 | 120 / 178 |
| brain | 99% | 315.44 | 2624 / 2642 | 59% | 1.33 | 415 / 705 |
| thymus | 99% | 274.91 | 644 / 653 | 53% | 1.21 | 322 / 605 |
| adrenal gland | 91% | 214.33 | 234 / 258 | 50% | 1.16 | 116 / 230 |
| prostate | 95% | 225.54 | 232 / 245 | 15% | 0.26 | 73 / 502 |
| intestine | 97% | 248.81 | 938 / 966 | 12% | 0.33 | 63 / 527 |
| spleen | 100% | 312.83 | 241 / 241 | 0% | 0 | 0 / 0 |
| lung | 81% | 129.13 | 471 / 578 | 13% | 0.24 | 146 / 1155 |
| blood vessel | 93% | 168.25 | 1241 / 1335 | 0% | 0 | 0 / 0 |
| bladder | 81% | 181.19 | 17 / 21 | 7% | 0.20 | 37 / 504 |
| heart | 87% | 181.06 | 745 / 861 | 0% | 0 | 0 / 0 |
| esophagus | 73% | 210.54 | 1056 / 1445 | 13% | 0.27 | 23 / 183 |
| uterus | 72% | 114.15 | 123 / 170 | 12% | 0.28 | 56 / 459 |
| stomach | 63% | 79.31 | 226 / 359 | 8% | 0.15 | 24 / 286 |
| breast | 59% | 58.37 | 273 / 459 | 11% | 0.22 | 127 / 1118 |
| ovary | 59% | 75.91 | 107 / 180 | 7% | 0.12 | 29 / 430 |
| adipose | 57% | 60.32 | 689 / 1204 | 0% | 0 | 0 / 0 |
| skin | 17% | 13.47 | 305 / 1809 | 28% | 0.69 | 131 / 472 |
| muscle | 39% | 40.29 | 311 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 23% | 0.54 | 18 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 0.27 | 5 / 29 |
| peripheral blood | 14% | 11.85 | 127 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 7% | 0.12 | 3 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0031639 | Biological process | plasminogen activation |
| GO_0007596 | Biological process | blood coagulation |
| GO_0002542 | Biological process | Factor XII activation |
| GO_0006508 | Biological process | proteolysis |
| GO_0051919 | Biological process | positive regulation of fibrinolysis |
| GO_0042730 | Biological process | fibrinolysis |
| GO_0031638 | Biological process | zymogen activation |
| GO_0005615 | Cellular component | extracellular space |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005515 | Molecular function | protein binding |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| Gene name | KLKB1 |
| Protein name | Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] Kallikrein B1 |
| Synonyms | KLK3 |
| Description | FUNCTION: Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. |
| Accessions | ENST00000428196.5 C9J075 ENST00000264690.11 C9JCT1 ENST00000446598.6 E9PBC5 P03952 ENST00000513864.2 |
