KLK14 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KLK14 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KLK14 at tissue level.

III. Associated gene sets

GO_0045744Biological processnegative regulation of G protein-coupled receptor signaling pathway
GO_0009566Biological processfertilization
GO_0070684Biological processseminal clot liquefaction
GO_0048730Biological processepidermis morphogenesis
GO_0006508Biological processproteolysis
GO_0045745Biological processpositive regulation of G protein-coupled receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0030141Cellular componentsecretory granule
GO_0005576Cellular componentextracellular region
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameKLK14
Protein nameKallikrein M (Kallikrein related peptidase 14)
Kallikrein-related peptidase 14 transcript variant 3
Kallikrein-related peptidase 14 transcript variant 2
Kallikrein-14 (hK14) (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6)
SynonymsKLKL6
KLK-L6
KLNM
DescriptionFUNCTION: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. .

AccessionsQ9P0G3
ENST00000391802.1
A0A1R3UHJ7
ENST00000156499.7
ENST00000650543.2
A0A3S6H8C4
A0A3Q8BCJ8