I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| goblet cell | 10 studies | 63% ± 19% | |
| intestinal crypt stem cell | 4 studies | 30% ± 19% | |
| epithelial cell | 3 studies | 22% ± 7% | |
| acinar cell | 3 studies | 79% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| goblet cell | 10 studies | 63% ± 19% | |
| intestinal crypt stem cell | 4 studies | 30% ± 19% | |
| epithelial cell | 3 studies | 22% ± 7% | |
| acinar cell | 3 studies | 79% ± 9% |
Insufficient scRNA-seq data for expression of KLK1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 100% | 83406.59 | 328 / 328 | 83% | 129.79 | 148 / 178 |
| intestine | 53% | 1224.00 | 513 / 966 | 92% | 58.85 | 483 / 527 |
| prostate | 54% | 222.59 | 132 / 245 | 56% | 4.81 | 283 / 502 |
| kidney | 80% | 2466.27 | 71 / 89 | 16% | 212.37 | 140 / 901 |
| skin | 72% | 1422.14 | 1300 / 1809 | 13% | 3.11 | 63 / 472 |
| stomach | 5% | 26.14 | 19 / 359 | 80% | 38.23 | 228 / 286 |
| spleen | 84% | 459.30 | 202 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 7% | 16.25 | 94 / 1445 | 55% | 10.56 | 100 / 183 |
| lymph node | 0% | 0 | 0 / 0 | 55% | 10.31 | 16 / 29 |
| uterus | 11% | 85.52 | 18 / 170 | 44% | 8.84 | 200 / 459 |
| thymus | 33% | 106.58 | 216 / 653 | 19% | 10.10 | 115 / 605 |
| adrenal gland | 33% | 140.09 | 86 / 258 | 15% | 46.29 | 35 / 230 |
| ovary | 1% | 0.84 | 1 / 180 | 44% | 5.95 | 190 / 430 |
| bladder | 0% | 0 | 0 / 21 | 36% | 16.61 | 182 / 504 |
| lung | 6% | 16.89 | 34 / 578 | 27% | 5.17 | 311 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 31% | 4.14 | 14 / 45 |
| peripheral blood | 20% | 643.47 | 189 / 929 | 0% | 0 | 0 / 0 |
| breast | 4% | 26.10 | 18 / 459 | 14% | 1.39 | 152 / 1118 |
| adipose | 9% | 49.84 | 114 / 1204 | 0% | 0 | 0 / 0 |
| liver | 0% | 1.25 | 1 / 226 | 3% | 0.31 | 11 / 406 |
| blood vessel | 1% | 17.19 | 16 / 1335 | 0% | 0 | 0 / 0 |
| heart | 1% | 3.49 | 10 / 861 | 0% | 0 | 0 / 0 |
| brain | 0% | 1.38 | 13 / 2642 | 0% | 0.02 | 2 / 705 |
| muscle | 0% | 0.99 | 3 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0003073 | Biological process | regulation of systemic arterial blood pressure |
| GO_0031638 | Biological process | zymogen activation |
| GO_0030141 | Cellular component | secretory granule |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| Gene name | KLK1 |
| Protein name | Kallikrein 1 isoform 3 preproprotein (Kallikrein 1, renal/pancreas/salivary, isoform CRA_c) Kallikrein 1 Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein) Kallikrein 1, renal/pancreas/salivary, isoform CRA_a (Kallikrein A1) Kallikrein-1 isoform 3 Kallikrein-1 isoform 4 |
| Synonyms | hK1 KLNA1 hCG_22931 KLKR Klk6 |
| Description | FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.; FUNCTION: (Microbial infection) Cleaves Neisseria meningitidis NHBA in saliva; Neisseria is an obligate commensal of the nasopharyngeal mucosa. . |
| Accessions | M0R318 P06870 ENST00000593325.5 Q6T776 A0A1L2BPJ1 A0A1R3UCD2 ENST00000301420.3 [P06870-1] A0A1L2BPJ2 |
