KLHL40 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KLHL40 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KLHL40 at tissue level.

III. Associated gene sets

GO_0048741Biological processskeletal muscle fiber development
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0098528Biological processskeletal muscle fiber differentiation
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0031674Cellular componentI band
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0031672Cellular componentA band
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKLHL40
Protein nameKelch-like protein 40 (Kelch repeat and BTB domain-containing protein 5) (Sarcosynapsin)
SynonymsSRYP
KBTBD5
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development . The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity). .

AccessionsENST00000287777.5 [Q2TBA0-1]
Q2TBA0