KLHL21 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KLHL21 at tissue level.

III. Associated gene sets

GO_0035853Biological processchromosome passenger complex localization to spindle midzone
GO_0016567Biological processprotein ubiquitination
GO_0051301Biological processcell division
GO_0032465Biological processregulation of cytokinesis
GO_0005829Cellular componentcytosol
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005827Cellular componentpolar microtubule
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0097602Molecular functioncullin family protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKLHL21
Protein nameKelch-like protein 21
KLHL21 protein
Alternative protein KLHL21
Kelch like family member 21
SynonymsKIAA0469
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. .

AccessionsENST00000377663.3 [Q9UJP4-2]
ENST00000467612.5
ENST00000463043.1
Q2NKK7
K7ELI0
L8E9P8
Q9UJP4
K7EMF2
ENST00000496707.5
ENST00000377658.8 [Q9UJP4-1]
K7ESH2