KLHL15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KLHL15 at tissue level.

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0071630Biological processnuclear protein quality control by the ubiquitin-proteasome system
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKLHL15
Protein nameKelch-like protein 15
Alternative protein KLHL15
SynonymsKIAA1677
hCG_1642367
HEL-S-305
DescriptionFUNCTION: Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex . Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits . Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation . Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) . .

AccessionsENST00000689334.1
ENST00000692681.1
ENST00000693269.1
V9HWF1
ENST00000328046.8
Q96M94
L8EB72
A0A8I5QJW5
ENST00000685367.1
ENST00000684871.1