KLHDC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0140627Biological processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO_0031466Cellular componentCul5-RING ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity

IV. Literature review

[source]
Gene nameKLHDC1
Protein nameKelch domain containing 1
Kelch domain-containing protein 1
SynonymsMSTP025
DescriptionFUNCTION: Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL5(KLHDC1) complex mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine . .

AccessionsENST00000555704.5
ENST00000556392.5
G3V5V5
ENST00000553274.1
G3V4I4
Q8N7A1
ENST00000557128.1
G3V3T1
G3V2D3
ENST00000359332.7