Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 10 studies | 28% ± 9% | |
astrocyte | 7 studies | 33% ± 12% | |
endothelial cell | 6 studies | 25% ± 9% | |
adipocyte | 6 studies | 24% ± 6% | |
GABAergic neuron | 5 studies | 39% ± 18% | |
microglial cell | 4 studies | 20% ± 4% | |
oligodendrocyte precursor cell | 4 studies | 30% ± 8% | |
fibroblast | 4 studies | 23% ± 10% | |
glutamatergic neuron | 3 studies | 61% ± 6% | |
macrophage | 3 studies | 19% ± 5% | |
endothelial cell of lymphatic vessel | 3 studies | 21% ± 4% | |
interneuron | 3 studies | 46% ± 21% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 46% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 594.55 | 2630 / 2642 | 100% | 8.46 | 702 / 705 |
prostate | 100% | 667.27 | 245 / 245 | 99% | 4.09 | 495 / 502 |
thymus | 100% | 826.11 | 653 / 653 | 98% | 6.81 | 595 / 605 |
adrenal gland | 99% | 390.29 | 256 / 258 | 97% | 6.63 | 223 / 230 |
ovary | 100% | 1183.83 | 180 / 180 | 92% | 2.76 | 397 / 430 |
kidney | 98% | 341.18 | 87 / 89 | 94% | 3.98 | 849 / 901 |
breast | 100% | 691.06 | 459 / 459 | 92% | 4.08 | 1024 / 1118 |
pancreas | 99% | 291.75 | 325 / 328 | 92% | 3.36 | 164 / 178 |
lung | 99% | 436.49 | 571 / 578 | 87% | 2.63 | 1005 / 1155 |
esophagus | 97% | 453.97 | 1408 / 1445 | 86% | 2.70 | 158 / 183 |
skin | 95% | 385.77 | 1724 / 1809 | 82% | 2.50 | 386 / 472 |
uterus | 100% | 867.57 | 170 / 170 | 74% | 1.83 | 340 / 459 |
stomach | 99% | 426.44 | 357 / 359 | 72% | 1.86 | 207 / 286 |
bladder | 100% | 604.81 | 21 / 21 | 64% | 1.47 | 322 / 504 |
intestine | 100% | 600.18 | 963 / 966 | 55% | 1.28 | 288 / 527 |
liver | 93% | 231.03 | 210 / 226 | 59% | 1.19 | 238 / 406 |
blood vessel | 100% | 629.36 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 516.65 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.52 | 1 / 1 |
adipose | 100% | 663.50 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 99% | 368.28 | 794 / 803 | 0% | 0 | 0 / 0 |
heart | 96% | 360.84 | 827 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 76% | 1.84 | 22 / 29 |
eye | 0% | 0 | 0 / 0 | 74% | 2.89 | 59 / 80 |
tonsil | 0% | 0 | 0 / 0 | 60% | 1.25 | 27 / 45 |
peripheral blood | 18% | 27.26 | 167 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0140627 | Biological process | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
GO_0031466 | Cellular component | Cul5-RING ubiquitin ligase complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
Gene name | KLHDC1 |
Protein name | Kelch domain containing 1 Kelch domain-containing protein 1 |
Synonyms | MSTP025 |
Description | FUNCTION: Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL5(KLHDC1) complex mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine . . |
Accessions | ENST00000555704.5 ENST00000556392.5 G3V5V5 ENST00000553274.1 G3V4I4 Q8N7A1 ENST00000557128.1 G3V3T1 G3V2D3 ENST00000359332.7 |