KL report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KL at tissue level.

III. Associated gene sets

GO_0055074Biological processcalcium ion homeostasis
GO_0042421Biological processnorepinephrine biosynthetic process
GO_0008340Biological processdetermination of adult lifespan
GO_0005975Biological processcarbohydrate metabolic process
GO_0014823Biological processresponse to activity
GO_0003085Biological processnegative regulation of systemic arterial blood pressure
GO_0090080Biological processpositive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO_0030501Biological processpositive regulation of bone mineralization
GO_0006112Biological processenergy reserve metabolic process
GO_0033280Biological processresponse to vitamin D
GO_1990776Biological processresponse to angiotensin
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0016324Cellular componentapical plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0008422Molecular functionbeta-glucosidase activity
GO_0005179Molecular functionhormone activity
GO_0004566Molecular functionbeta-glucuronidase activity
GO_0005499Molecular functionvitamin D binding
GO_0005104Molecular functionfibroblast growth factor receptor binding
GO_0017134Molecular functionfibroblast growth factor binding

IV. Literature review

[source]
Gene nameKL
Protein nameKlotho (EC 3.2.1.31) [Cleaved into: Klotho peptide]
Synonyms
DescriptionFUNCTION: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). .; FUNCTION: The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. .

AccessionsQ9UEF7
ENST00000380099.4 [Q9UEF7-1]