KIRREL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0098609Biological processcell-cell adhesion
GO_0003094Biological processglomerular filtration
GO_0097017Biological processrenal protein absorption
GO_0045217Biological processcell-cell junction maintenance
GO_0005911Cellular componentcell-cell junction
GO_0045121Cellular componentmembrane raft
GO_0005886Cellular componentplasma membrane
GO_0031253Cellular componentcell projection membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0043198Cellular componentdendritic shaft
GO_0050839Molecular functioncell adhesion molecule binding
GO_0017022Molecular functionmyosin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKIRREL1
Protein nameKin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)
Kirre like nephrin family adhesion molecule 1 (cDNA FLJ56360, highly similar to Kin of IRRE-like protein 1)
Kirre like nephrin family adhesion molecule 1
SynonymsKIRREL
NEPH1
DescriptionFUNCTION: Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm . It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). .

AccessionsB4DN67
ENST00000368173.7
ENST00000360089.8
ENST00000368172.2
ENST00000359209.11 [Q96J84-1]
Q96J84
Q5W0F9
Q5W0G0