KIR2DL3 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	9 studies	23% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	23% ± 7%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KIR2DL3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
spleen	100%	79.04	241 / 241	0%	0	0 / 0
lung	91%	29.82	524 / 578	4%	0.09	41 / 1155
peripheral blood	80%	263.96	740 / 929	0%	0	0 / 0
adipose	47%	6.05	564 / 1204	0%	0	0 / 0
liver	36%	3.59	81 / 226	1%	0.02	4 / 406
breast	34%	4.54	154 / 459	2%	0.04	25 / 1118
thymus	28%	2.77	180 / 653	1%	0.01	7 / 605
uterus	21%	2.99	36 / 170	5%	0.32	22 / 459
kidney	17%	1.17	15 / 89	5%	0.09	45 / 901
bladder	19%	1.90	4 / 21	3%	0.11	14 / 504
intestine	15%	1.53	141 / 966	3%	0.04	14 / 527
ovary	13%	1.47	23 / 180	3%	0.23	12 / 430
heart	15%	1.31	132 / 861	0%	0	0 / 0
stomach	7%	0.65	26 / 359	4%	0.07	12 / 286
prostate	11%	0.83	26 / 245	0%	0.02	2 / 502
blood vessel	11%	1.09	143 / 1335	0%	0	0 / 0
adrenal gland	9%	0.92	23 / 258	2%	0.03	4 / 230
lymph node	0%	0	0 / 0	10%	1.85	3 / 29
esophagus	6%	0.49	88 / 1445	4%	0.08	7 / 183
tonsil	0%	0	0 / 0	7%	0.13	3 / 45
muscle	6%	0.50	48 / 803	0%	0	0 / 0
skin	3%	0.27	59 / 1809	2%	0.04	11 / 472
brain	5%	0.37	128 / 2642	0%	0.00	1 / 705
pancreas	2%	0.12	7 / 328	0%	0	0 / 178
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

IV. Literature review

[source]

Gene name	KIR2DL3
Protein name	KIR2DL2 (Killer cell immunoglobulin-like receptor 2DL2) (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 2) Natural killer cell inhibitory receptor Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2) KIR2DL2 (Killer cell immunoglobulin-like receptor) KIR2DL3 protein KIR2DL3 Killer cell immunoglobulin-like receptor 2DL2 KIR2DL3 (Killer cell immunoglobulin-like receptor) Natural killer-associated transcript 2 Killer cell immunoglobulin-like receptor (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 3) Killer cell immunoglobulin-like receptor 2DL3
Synonyms	KIRCL23 KIR2DL32DL300501_extension_1 KIR2DL2 CD158B2 KIR2DL32DL300110_extension_1 NKAT2
Description	FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
Accessions	K7QT48 ENST00000617853.1 ENST00000619995.4 [P43628-1] ENST00000611206.4 A0A0C4ZLV8 A0A376A8J1 Q32WE4 ENST00000614792.4 [P43628-1] ENST00000639089.2 [P43628-1] A0A0G2JNW9 ENST00000617820.3 C6EVS2 E3NZD8 ENST00000617404.1 [P43628-1] Q9UPI8 ENST00000617790.4 [P43628-1] ENST00000612594.1 A0A376A8S8 ENST00000342376.4 [P43628-1] ENST00000639108.2 ENST00000614650.4 A0A376A8U6 A0A0G2JPP8 ENST00000622644.4 [P43628-1] ENST00000619702.1 [P43628-1] ENST00000617150.4 ENST00000638851.2 [P43628-1] ENST00000640262.2 A0A376A8L8 C6EVR6 ENST00000640323.2 A0A376A8T5 ENST00000616520.4 ENST00000617242.4 [P43628-1] ENST00000610407.4 Q8N742 ENST00000617593.4 [P43628-1] A0A2R4FYL5 ENST00000640389.2 ENST00000618870.1 P43628 ENST00000622658.4 ENST00000611990.4 [P43628-1] ENST00000615091.4 [P43628-1] C6EVR7 ENST00000639101.2 [P43628-1] ENST00000620549.4 [P43628-1] ENST00000639176.2 [P43628-1] C6EVS1 ENST00000640485.2 [P43628-1] ENST00000638813.2 [P43628-1] A0A2I2JL05 ENST00000611207.4 [P43628-1] ENST00000621461.4 E3NZD3 E3NZD7 ENST00000639124.2 ENST00000622560.4 A0A191URJ0 ENST00000611821.4 [P43628-1] ENST00000615739.1 ENST00000611369.4 [P43628-1]

GO_0006955	Biological process	immune response
GO_0002764	Biological process	immune response-regulating signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0003823	Molecular function	antigen binding
GO_0038023	Molecular function	signaling receptor activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

KIR2DL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review