I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| CD16-positive, CD56-dim natural killer cell, human | 6 studies | 19% ± 5% | |
| natural killer cell | 3 studies | 25% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| CD16-positive, CD56-dim natural killer cell, human | 6 studies | 19% ± 5% | |
| natural killer cell | 3 studies | 25% ± 9% |
Insufficient scRNA-seq data for expression of KIR2DL1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 97% | 62.21 | 559 / 578 | 4% | 0.75 | 45 / 1155 |
| spleen | 100% | 129.47 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 81% | 391.81 | 751 / 929 | 0% | 0 | 0 / 0 |
| adipose | 58% | 9.59 | 700 / 1204 | 0% | 0 | 0 / 0 |
| liver | 57% | 8.73 | 128 / 226 | 0% | 0.02 | 2 / 406 |
| thymus | 44% | 5.47 | 290 / 653 | 1% | 0.01 | 4 / 605 |
| breast | 43% | 7.06 | 198 / 459 | 2% | 0.12 | 17 / 1118 |
| kidney | 28% | 3.43 | 25 / 89 | 5% | 0.07 | 41 / 901 |
| bladder | 29% | 3.29 | 6 / 21 | 2% | 0.11 | 11 / 504 |
| uterus | 25% | 3.45 | 43 / 170 | 3% | 0.15 | 15 / 459 |
| heart | 27% | 2.91 | 231 / 861 | 0% | 0 | 0 / 0 |
| ovary | 17% | 1.68 | 30 / 180 | 1% | 0.02 | 6 / 430 |
| intestine | 13% | 1.56 | 129 / 966 | 2% | 0.04 | 13 / 527 |
| blood vessel | 13% | 1.38 | 175 / 1335 | 0% | 0 | 0 / 0 |
| esophagus | 11% | 0.94 | 152 / 1445 | 2% | 0.03 | 4 / 183 |
| prostate | 12% | 0.96 | 30 / 245 | 0% | 0.09 | 2 / 502 |
| adrenal gland | 12% | 1.42 | 30 / 258 | 1% | 0.01 | 2 / 230 |
| stomach | 9% | 0.91 | 32 / 359 | 3% | 0.06 | 10 / 286 |
| muscle | 10% | 0.86 | 83 / 803 | 0% | 0 | 0 / 0 |
| brain | 8% | 0.72 | 221 / 2642 | 0% | 0.00 | 1 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.97 | 2 / 29 |
| skin | 4% | 0.37 | 76 / 1809 | 1% | 0.03 | 7 / 472 |
| pancreas | 3% | 0.20 | 9 / 328 | 0% | 0 | 0 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.02 | 1 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006955 | Biological process | immune response |
| GO_0002769 | Biological process | natural killer cell inhibitory signaling pathway |
| GO_0002764 | Biological process | immune response-regulating signaling pathway |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KIR2DL1 |
| Protein name | Natural killer cell inhibitory receptor KIR2DL protein (Killer cell immunoglobulin-like receptor) Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 1 KIR2DL1 (Killer cell immunoglobulin-like receptor) (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 1) (Natural killer cell inhibitory receptor) Killer cell immunoglobulin-like receptor 2DL1 (CD158 antigen-like family member A) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor CL-42/47.11) (p58.1 MHC class-I-specific NK receptor) (CD antigen CD158a) KIR2DL1 Killer cell immunoglobulin-like receptor 2DL1 Killer cell immunoglobulin-like receptor (Natural killer cell inhibitory receptor) KIR2DL1 (Killer cell immunoglobulin-like receptor) (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 1) Killer cell immunoglobulin-like receptor HCG2043595, isoform CRA_a (KIR2DL1) (Killer cell immunoglobulin-like receptor 2DL1) KIR2DL1 (Killer cell immunoglobulin-like receptor) KIR2DL1 protein (Killer cell immunoglobulin-like receptor 2DL1) KIR2DL1 protein |
| Synonyms | hCG_2043595 NKAT1 CD158A 3DL2 LOC112267881 |
| Description | FUNCTION: Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. . |
| Accessions | ENST00000616631.1 ENST00000291633.7 [P43626-2] ENST00000613465.4 A0A2R8A5N5 E0X066 ENST00000610327.4 [P43626-1] A0A376A8M1 ENST00000619424.1 [P43626-1] A0A1B5BA04 ENST00000611594.1 [P43626-1] ENST00000639517.1 ENST00000639188.2 ENST00000615298.1 [P43626-1] A0A0G2JQ05 ENST00000610627.1 [P43626-1] ENST00000638700.1 ENST00000622463.4 A0A1B5BA03 ENST00000613580.1 ENST00000639765.2 ENST00000672897.1 ENST00000639230.2 [P43626-1] ENST00000638780.1 [P43626-2] ENST00000645403.2 Q6H2H1 K7R1R8 A0A191URH2 ENST00000617247.1 [P43626-1] E7BWS2 A0A0C4ZNX3 A0A2I2JL20 Q6H2H2 E7BWS0 C6ZNL5 E0X064 ENST00000336077.11 [P43626-1] ENST00000616076.4 [P43626-1] ENST00000639917.2 [P43626-1] A0A2R8A5N3 ENST00000616310.1 [P43626-1] A0A0G2JQ06 Q1KMT8 A0A2I2JL10 A0A0G2JNM5 C6ZNL7 A0A0G2JQ35 P43626 ENST00000676872.1 E7BWS1 E7BWR8 A0A2R8A5M1 ENST00000640106.1 ENST00000611611.4 ENST00000640546.1 C6ZNL4 ENST00000640308.2 [P43626-1] C6ZNL6 A0A6G6CYT8 ENST00000614185.1 A0A0G2JND8 A0A2R8A5L3 A0A7D5CA51 A0A191URJ7 Q6H2H4 ENST00000612504.1 [P43626-1] A0A5K1VDZ0 ENST00000614564.1 A0A1B5BA00 ENST00000618507.1 [P43626-1] ENST00000638777.2 A0A6G6CYT7 ENST00000677749.1 ENST00000640477.2 [P43626-1] A0A0G2JPY8 A0A1W2PRZ1 ENST00000617127.4 ENST00000612069.1 ENST00000616175.1 ENST00000618987.1 [P43626-1] A0A5J6VPP5 ENST00000640661.1 ENST00000612312.1 A0A376A8U5 C6ZNL3 ENST00000618563.1 [P43626-2] ENST00000640259.2 ENST00000673185.1 ENST00000640661.1 [P43626-2] ENST00000640546.1 [P43626-2] ENST00000639616.1 [P43626-2] A0A6G6CYU1 ENST00000639616.1 ENST00000616302.4 [P43626-1] ENST00000620449.1 [P43626-2] ENST00000611849.1 ENST00000639974.1 ENST00000638780.1 ENST00000620588.1 [P43626-1] ENST00000615920.4 E7BWS3 ENST00000617376.1 [P43626-2] ENST00000639720.2 ENST00000616642.1 |
