KIF7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KIF7 at tissue level.

III. Associated gene sets

GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0007018Biological processmicrotubule-based movement
GO_0097542Cellular componentciliary tip
GO_0005929Cellular componentcilium
GO_0036064Cellular componentciliary basal body
GO_0005871Cellular componentkinesin complex
GO_0005874Cellular componentmicrotubule
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0003777Molecular functionmicrotubule motor activity
GO_0008017Molecular functionmicrotubule binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameKIF7
Protein nameKinesin family member 7
Kinesin-like protein KIF7
KIF7 protein
SynonymsUNQ340/PRO539
DescriptionFUNCTION: Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms . Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). .

AccessionsENST00000394412.8
Q2M1P5
ENST00000445906.1
A0A8Q3SIQ8
ENST00000696512.1
A0A7I2V527
F8WD21
ENST00000558928.1
B7ZKY4